Aminotriazine 5-HT7 antagonists

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4245-8. doi: 10.1016/j.bmcl.2004.06.008.

Abstract

The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist.

MeSH terms

  • Dose-Response Relationship, Drug
  • Receptors, Serotonin / drug effects*
  • Serotonin Antagonists / pharmacology*
  • Triazines / pharmacology*

Substances

  • Receptors, Serotonin
  • Serotonin Antagonists
  • Triazines
  • serotonin 7 receptor